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For a long time, metabolism has been viewed as a static series of biochemical reactions. Cellular metabolism is indeed however highly dynamic, and is implicated in many biologically important phenomena, such as ageing, cellular robustness, and adaptation to ever changing environments. These properties bring metabolism center-stage both for developing therapies against cancer and neurodegenerative disorders and for understanding the ageing process.We investigate regulatory functions of the metabolic network and how its dynamics are maintained. We do this by combining methods of functional genomics with mass spectrometry, and systematically identify gene-metabolism interactions, study how cells cooperate in metabolism, and how metabolism evolves.We address these questions often in the yeast Saccharomyces cerevisiae. Working with this single-cellular eukaryote removes some complexity from our investigations, as a plethora of genetic and biochemical techniques are available, reducing bias from altered metabolic activity that is found in cell culture systems, allowing us to work with hundreds to thousands of mutants in parallel. The simplicity of the model organism on the one hand, enables us to be a 'Multi-Omic' laboratory that adresses some of the most complex biological questions, on the other hand.Our research team was founded as the 'Molecular Biology of Metabolism group' at the Department of Vertebrate Genomics Max Planck Institute for Molecular Genetics in Berlin in 2007, before moving to the Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge. Starting as compuational lab at the MRC-NIMR in Mill Hill, the lab is loacted at the Francis Crick Institute, London, since December 2016.

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